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Common uses

Generic Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) known as a COX-2 inhibitor. It is used to relieve pain and swelling (inflammation). It is used to treat arthritis, acute pain, and menstrual pain and discomfort. Celecoxib is also used to decrease growths found in the intestines (colon polyps) in persons with a family history of this condition. This drug works by blocking the enzyme in your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain and swelling.

Before using

Some medicines or medical conditions may interact with Generic Celecoxib. Additional monitiring of your dose or condition may be needed if you are taking fluconazole, lithium, "water pills" (diuretics such as furosemide, hydrochlorothiazide, triamterene), high blood pressure medicines (e.g., ACE inhibitors such as captopril and lisinopril), corticosteroids such as prednisone, "blood thinners" such as warfarin, other NSAIDs such as aspirin or ibuprofen, or other COX-2 inhibitors such as rofecoxib or valdecoxib. Inform your doctor of any other medical conditions including kidney problems, liver problems, heart disease (e.g., high blood pressure, congestive heart failure), alcohol use, swelling (edema), blood disorders (anemia), serious infections, stomach problems (bleeding or ulcers), dehydration, poorly controlled diabetes, asthma, growths in the nose (nasal polyps), any allergies (especially to aspirin/NSAIDs such as ibuprofen, COX-2 inhibitors such as rofecoxib, or to sulfa medicines), pregnancy, or breast-feeding.

Directions

To decrease the chance of stomach upset, take Generic Celecoxib with food. Take this medication by mouth with a full glass of water (8oz/240ml). Do not lie down for at least 30 minutes after taking Generic Celecoxib. Store Generic Celecoxib at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not store in the bathroom.

If you miss a dose of Generic Celecoxib, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Cautions

Do not take Generic Celecoxib if you have had a severe allergic reactoin to aspirin or any medicine containing aspirin or to a nonsteroidal anti-inflammatory drug (such as piroxicam, ibuprofen, naproxen, sulindac).

Do not take Generic Celecoxib if you have had a severe allergic reactoin to a sulfonamide antibiotic (such as sulfamethoxazole or sulfisoxazole). A severe reaction includes a severe rash, hives, breathing difficulties, or dizziness.

Do not exceed the recommended dose or take Generic Celecoxib for longer than prescribed. Generic Celecoxib may cause stomach bleeding. Alcohol use combined with Generic Celecoxib may increase your risk for stomach bleeding.

Before you begin taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes any medicines that may contain aspirin, ibuprofen, naproxen, or ketoprofen. Aspirin as prescribed by your doctor for reasons such as heart attack or stroke prevention (usually 81-325 mg per day) should be discussed with your doctor before combining with Generic Celecoxib. Caution is advised when using Generic Celecoxib in the elderly since they may be more sensitive to the side effects of Generic Celecoxib (especially to stomach bleeding and kidney effects).

For women: Generic Celecoxib should be used only when clearly needed during the first 6 months of pregnancy. It should not be used during the last 3 months of pregnancy. Generic Celecoxib may be excreted in breast milk. Do not breast-feed while taking Generic Celecoxib.

Possible side effects

Side effects that may occur while taking Generic Celecoxib include stomach upset or gas. Check with your doctor as soon as possible if you experience severe headache, unexplained weight gain, swelling of the hands or feet, or change in amount of urine.

Generic Celecoxib may rarely cause serious (possibly fatal) bleeding from the stomach or intestines; therefore, stop taking Generic Celecoxib if you experience any of the following: black stools, vomit that looks like coffee grounds, persistent stomach/abdominal pain.

Generic Celecoxib may rarely cause serious (possibly fatal) liver disease; therefore, contact your doctor if you experience any of the following: yellowing eyes or skin, dark urine, persistent stomach/abdominal pain, unusual fatigue; difficulty breathing; dizziness; tightness of chest; swelling of eyelids, face, or lips; or if you develop a rash or hives.

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Cardiovascular Risk

· CELEBREX may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. All NSAIDs may have a similar risk. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (see WARNINGS and CLINICAL TRIALS).

· CELEBREX is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Gastrointestinal Risk

· NSAIDs, including CELEBREX, cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (see WARNINGS).

 


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