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FDA Asks Purdue Pharma to Withdraw Palladone for Safety Reasons
After acquiring new information that serious and potentially fatal adverse reactions can occur when Palladone (hydromorphone hydrochloride) extended release capsules are taken together with alcohol, the U.S. Food and Drug Administration has asked Purdue Pharma L.P., the makers of the drug, to withdraw it from the market.

FDA Issues Public Health Advisory on the Fentanyl Patch
The FDA today issued a Public Health Advisory regarding the safe use of transdermal fentanyl patches in response to reports of deaths in patients using this potent narcotic medication for pain management. In addition, a patient information sheet and an alert to healthcare professionals were issued identifying several important safety precautions for the use of fentanyl transdermal patches. These safety precautions include but are not limited to patient education regarding signs of overdose, proper patch application, use of other medications while using the patch, safeguards for children, and proper storage and disposal.


Pain Relief Improves Fibromyalgia Sufferers' Lives
New research indicates that moderate-to-severe fibromyalgia pain can dramatically impair health-related quality of life for people with the condition. The good news is that effective pain relief can greatly improve the situation.

Slow-release painkillers and alcohol could be fatal combo: Health Canada
Slow-release painkillers known as opioids and any amount of alcohol could be a fatal combination, Health Canada warned Wednesday.

Some Pain Relievers May Raise Blood Pressure
Higher daily doses of some commonly used non-aspirin pain-relievers increase the risk of high blood pressure in women, the results of two studies suggest. "Our results have substantial public health implications," the researchers write, "and suggest that these agents be used with greater caution."

Butalbital in the treatment of headache: history, pharmacology, and efficacy
Analgesics containing butalbital compounded with aspirin, acetaminophen, and/or caffeine are widely used for the treatment of migraine and tension-type headache.

Conflicting Results on Painkillers and Breast Cancer
A new study is adding to the debate about whether common painkillers such as aspirin and ibuprofen protect against breast cancer. The latest research suggests they don't -- and that long-term use may even raise the risk of developing this disease.

Severe Migraines Do Not Need Narcotic Pain Drugs
Patients who show up in the ER with severe migraines are often given narcotic drugs to control their pain, but new research suggests that a drug called ketorolac (Toradol) may be a better alternative to the habit-forming agents.

Evaluating the safety and tolerability profile of acute treatments for migraine.
Among the medications that have been used as acute treatments for migraine are nonspecific agents, including nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics (either single or combination), and narcotics, as well as migraine-specific medications, including ergot alkaloids and triptans (5-hydroxytryptamine 1B/1D agonists).

Stability of barbiturates in fixed tissues and formalin solutions.
Stability of barbiturates in fixed tissues and formalin solutions.

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