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Drug Information: Norelgestromin and Ethinyl Estradiol Transdermal SystemURL of this page: http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a602006.html (nor el jes' troe min) (eth' in il es tra dye' ole)IMPORTANT WARNING:
Why is this medication prescribed?Norelgestromin and ethinyl estradiol transdermal system (patch) is used to prevent pregnancy. Norelgestromin is a progestin and ethinyl estradiol is an estrogen. Estrogen and progestin are two female sex hormones. Norelgestromin and ethinyl estradiol contraceptive patch works by preventing the release of eggs from the ovaries (ovulation) and changing the cervical mucus and the lining of the uterus. The contraceptive patch is a very effective method of birth control, but it does not prevent the spread of AIDS and other sexually transmitted diseases. How should this medicine be used?Norelgestromin and ethinyl estradiol transdermal system comes as a patch to apply to the skin. One patch is applied once a week for 3 weeks, followed by a patch-free week. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use the contraceptive patch exactly as directed. If you are using the contraceptive patch for the first time, wait for the first day of your menstrual period to apply the first patch. You may choose to start applying the patch on the first Sunday after your period begins. If you begin applying the patch after Day 1 of the menstrual cycle, you must use a backup method of birth control (such as a condom and/or a spermicide) for the first 7 days of the first cycle. A new patch should always be applied on the same day of the week (the Patch Change Day). Apply a new patch once a week for 3 weeks. During Week 4, do not apply a patch, and expect to begin your menstrual period. On the day after Week 4 ends, apply a new patch to start a new 4-week cycle. You should not go more than 7 days without a patch. Apply the contraceptive patch to a clean, dry, intact, healthy area of skin on the buttock, abdomen, upper outer arm, or upper torso, in a place where it will not be rubbed by tight clothing. Do not place the contraceptive patch on the breasts or on skin that is red, irritated, or cut. Do not apply makeup, creams, lotions, powders, or other topical products to the skin area where the contraceptive patch is placed. Each new patch should be applied to a new spot on the skin to help avoid irritation. To apply the contraceptive patch, follow these steps:
Check your patch every day to make sure it is sticking. If the patch becomes partially or completely detached for less than one day, try to reapply it in the same place or replace it with a new patch immediately. Your Patch Change Day will stay the same. If the patch has become partially or completely detached for more than one day, you may not be protected from pregnancy. You must start a new cycle by applying a new patch immediately; the day that you apply the new patch becomes your new Patch Change Day. Use backup birth control for the first week of the new cycle. Other uses for this medicineThis medication may be prescribed for other uses; ask your doctor or pharmacist for more information. What special precautions should I follow?Before using norelgestromin and ethinyl estradiol contraceptive patch,
What special dietary instructions should I follow?Unless your doctor tells you otherwise, continue your normal diet. What should I do if I forget a dose?If you forget to change your patch at the start of any patch cycle (Week 1, Day 1), you may not be protected from pregnancy. Apply the first patch of the new cycle as soon as you remember. There is now a new Patch Change Day and a new Day 1. Use a backup method of birth control for one week. If you forget to change your patch in the middle of the patch cycle (Week 2 or Week 3) for 1 or 2 days, apply a new patch immediately and apply the next patch on your usual Patch Change Day. If you forget to change your patch in the middle of the cycle for more than 2 days, you may not be protected from pregnancy. Stop the current cycle and start a new cycle immediately by applying a new patch. There is now a new Patch Change Day and a new Day 1. Use a backup method of birth control for 1 week. If you forget to remove your patch at the end of the patch cycle (Week 4), take it off as soon as you remember. Start the next cycle on the usual Patch Change Day, the day after Day 28. If you forget to apply a new patch at the beginning of the new cycle (i.e. there are more than 7 patch-free days), you may not be protected from pregnancy. Use a backup method of birth control for 1 week. What side effects can this medication cause?Norelgestromin and ethinyl estradiol contraceptive patch may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:
Norelgestromin and ethinyl estradiol contraceptive patch may increase the risk of developing endometrial and breast cancer, gallbladder disease, liver tumors, heart attack, stroke, and blood clots. Talk to your doctor about the risks of using this medication. Norelgestromin and ethinyl estradiol contraceptive patch may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. What storage conditions are needed for this medicine?Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication. In case of emergency/overdoseIn case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911. What other information should I know?Keep all appointments with your doctor and the laboratory. You should have a complete physical examination every year, including blood pressure measurements, breast and pelvic exams, and a Pap test. Follow your doctor's directions for examining your breasts; report any lumps immediately. Before you have any laboratory tests, tell the laboratory personnel that you use norelgestromin and ethinyl estradiol contraceptive patch, as this medication may interfere with some laboratory tests. Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription. Brand name(s):
Other name(s):
For Professional Purpose: ORTHO EVRA is a thin, matrix-type transdermal contraceptive patch consisting of three layers. The backing layer is composed of a beige flexible film consisting of a low-density pigmented polyethylene outer layer and a polyester inner layer. It provides structural support and protects the middle adhesive layer from the environment. The middle layer contains polyisobutylene/polybutene adhesive, crospovidone, non-woven polyester fabric and lauryl lactate as inactive components. The active components in this layer are the hormones, norelgestromin and ethinyl estradiol. The third layer is the release liner, which protects the adhesive layer during storage and is removed just prior to application. It is a transparent polyethylene terephthalate (PET) film with a polydimethylsiloxane coating on the side that is in contact with the middle adhesive layer. The outside of the backing layer is heat-stamped 2ORTHO EVRAò 150/20.2 The structural formulas of the components are:
Molecular weight, norelgestromin: 327.47
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