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Tramadol for Headache

Tramadol is a relatively mild opioid-like analgesic. Many of the analgesics currently used for tension headache contain caffeine, or are anti-inflammatories. Tramadol avoids the problems inherent with these compounds.

Tramadol in the treatment of migraine without aura: a controlled trial vs placebo

Q. Zanchin. F. Maggionil, M.G. Buzzi, M. lannacone, B. Amantea, V. Gallai, A. Alberti, G. Relja, G. Sandrini, G. Nappi
Centro Cefalee, Clinica Neurologica I, Univ. PD; 4RCSS, NEUROMED, Pozzilli (IS); Anest. Rian., Policlinico Mater Domini, CZ; Clin. Neurol., Policlinico Monteluce, PG;
Centro Cefalee U.0. Neurol., Osp. Maggiore, TS; 'Centro Interuniversitario Studio Cefalee, 1st. Neurol. C. Mondino, PV

Aim of investigation: this multicenter, double-blind crossover, randomized, placebo controlled trial was conducted to check the efficacy of tramadol in the treatment of migraine without aura.
Methods: a total of 38 patients (9 men, 29 women) were treated with 20 drops orally whenever they had a migraine attack, they could repeat the dose (20 drops) at 30 minute intervals during the first 2 h if pain relief was insufficient. Each patient had to treat four successive migraine attacks (two pairs).
Results: the clinical evaluation was performed on 48 complete pairs of attacks in 30 patients. Rescue medications in the first two hours were required in 13 cases with placebo and 6 with tramadol. The number of migraine attacks relieved within two hours (primary efficacy) was reached by 16 patients taking tramadol and 6 with placebo, and tramadol had a useful effect regardless of whether it was given before or after placebo. During the study 15 patients treated with tramadol reported adverse events, mainly dizziness, nausea and vomiting.
Conclusions: In this first systematic trial in patients with migraine without aura tramadol showed better analgesic Йспоп than placebo in relieving pain, but to confirm these results, additional clinical trials should be performed in a larger study population.
Acknowledgements: Medical Department, Formenti -Griinenthal (Italy)

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Tramadol in the treatment of tension headache: a controlled trial vs placebo

G. Sandrini, G. Nappi, G. Bussone, L. Grazzi, F. Puca, S. Genco, E. Stemieri, A. Pini
Centro Interuniversitario Studio Cefalee, Istituto Neurologico C. Mondino, PV, Istituto Neurologico C. Besta, MI; Servizio Cefalee di Interesse Neurologico, Policlinico, BA;
Centro per lo Studio delle Cefalee, Policlinico, МО

Aim of investigation: the trial was conducted in four Italian headache centres to compare the activity of tramadol in patients with a diagnosis of tension headache according to the IHS classification.
Methods: thirty-seven patients (11 male, 26 female), mean (SD) age 33.1 ± 10.8 years were treated with tramadol or placebo with 20 drops that should be repeated every 30 minutes in the first 2 h if pain relief was insufficient. A double blind cross-over, experimental design was employed. Each patient had to treat six successive tension headache attacks (three pairs), with a 48-hour wash out between one attack and the next.
Results: the clinical evaluation was performed on 41 complete pairs of attacks in 23 patients. Tramadol limited the severity of the attacks in 41% of patients at 2 h, compared to 19.4% with placebo (p=0.0171) and the number of tension headache attacks resolved within 2 h was reached by more patients taking tramadol than placebo (16 vs 6). During the trial 14 patients treated with tramadol complained adverse events, mainly dizziness, pruritus and vomiting.
Conclusions: tramadol in this first controlled trial in patients with tension headache showed better analgesic action than placebo. To support these results should be performed additional trials in a larger study population.
Acknowledgements: Medical Department, Formenti-Grunenthal (Italy).

 

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Medical Encyclopedia: Headache

URL of this page: http://www.nlm.nih.gov/medlineplus/ency/article/003024.htm

Alternative names   

Pain - head

Definition   

A headache is pain or discomfort in the head, scalp, or neck. Serious causes of headaches are extremely rare. Most people with headaches can feel much better by making lifestyle changes, learning ways to relax, and occasionally by taking medications.

See also:

  • Tension headache
  • Cluster headache
  • Migraine with aura
  • Migraine without aura

Common Causes   

Tension headaches are due to tight, contracted muscles in your shoulders, neck, scalp, and jaw. They are often related to stress, depression, or anxiety. Overworking, not getting enough sleep, missing meals, and using alcohol or street drugs can make you more susceptible to them. Headaches can be triggered by chocolate, cheese, and monosodium glutamate (MSG). People who drink caffeine can have headaches when they don't get their usual daily amount.

Other common causes include:

  • Holding your head in one position for a long time, like at a computer, microscope, or typewriter
  • Poor sleep position
  • Overexerting yourself
  • Clenching or grinding your teeth

Tension headaches tend to be on both sides of your head. They often start at the back of your head and spread forward. The pain may feel dull or squeezing, like a tight band or vice. Your shoulders, neck, or jaw may feel tight and sore.

Migraine headaches are severe, recurrent headaches generally accompanied by other symptoms like visual disturbances or nausea. They tend to begin on one side of your head, although the pain may spread to both sides. You may have an "aura" (warning symptoms that start before your headache) and feel throbbing, pounding, or pulsating pain.

For information on migraine, see migraine headache.

Other types of headaches:

  • Cluster headaches are sharp, extremely painful headaches that tend to occur several times per day for months and then go away for a similar period. They are far less common.
  • Sinus headaches cause pain in the front of your head and face. They are due to inflammation in the sinus passages that lie behind the cheeks, nose, and eyes. The pain tends to be worse when you bend forward and when you first wake up in the morning. Postnasal drip, sore throat, and nasal discharge usually occur with these headaches.

Headaches may occur if you have a cold, the flu, fever, or premenstrual syndrome.

If you are over age 50 and are experiencing headaches for the first time, a condition called temporal arteritis may prove to be the cause. Symptoms of this condition include impaired vision and pain aggravated by chewing. There is a risk of becoming blind with this condition. Therefore, it must be treated by your doctor right away.

Rare causes of headache include:

  • Brain aneurysm -- a weakening of the wall of a blood vessel that can rupture and bleed into the brain
  • Brain tumor
  • Stroke or TIA
  • Brain infection like meningitis or encephalitis

Home Care   

Keep a headache diary to help identify the source or trigger of your symptoms. Then modify your environment or habits to avoid future headaches. When a headache occurs, write down the date and time the headache began, what you ate for the past 24 hours, how long you slept the night before, what you were doing and thinking about just before the headache started, any stress in your life, how long the headache lasts, and what you did to make it stop. After a period of time, you may begin to see a pattern.

A headache may be relieved by resting with your eyes closed and head supported. Relaxation techniques can help. A massage or heat applied to the back of the upper neck can be effective in relieving tension headaches.

Try acetaminophen, aspirin, or ibuprofen for tension headaches. DO NOT give aspirin to children because of the risk of Reye's syndrome.

Migraine headaches may respond to aspirin, naproxen, or combination migraine medications.

If over-the-counter remedies do not control your pain, talk to your doctor about possible prescription medications.

Prescription medications used for migraine headaches include ergotamine, dihydroergotamine, ergotamine with caffeine (Cafergot), isometheptene (Midrin), and triptanes like sumatriptan (Imitrex), rizatriptan (Maxalt), almotriptan (Axert), andzolmitriptan (Zomig). Sometimes medications to relieve nausea and vomiting are helpful for other migraine symptoms.

If you get headaches often, your doctor may prescribe medication to prevent headaches before they occur. Examples of these include:

  • Antidepressants, like nortriptyline (Pamelor), amitriptyline (Elavil), fluoxetine (Prozac, Sarafem), sertraline (Zoloft), or paroxetine (Paxil), for tension or migraine headache
  • Beta-blockers, like propranolol (Inderal) for frequent migraine headaches
  • Calcium channel blockers, like verapamil for frequent migraine headaches

If you are using pain medications more than 2 days a week, you may be suffering from rebound headaches. Rebound headaches are caused by a cycle of using pain medications for short-term relief, followed by the headache pain returning for increasingly longer periods of time despite taking more pain medications.

All types of pain pills (including over-the-counter drugs), muscle relaxants, some decongestants, and caffeine can cause this pattern. If you think this may be a problem for you, talk to your health care provider.

Call your health care provider if   

Take the following symptoms seriously. If you cannot see your health care provider immediately, go to the emergency room or call 911:

  • Your headache comes on suddenly and is explosive or violent.
  • You would describe your headache as "your worst ever", even if you are prone to headaches.
  • Your headache is associated with slurred speech, change in vision, problems moving your arms or legs, loss of balance, confusion, or memory loss.
  • Your headache gets progressively worse over a 24-hour period.
  • Your headache is accompanied by fever, stiff neck, nausea, and vomiting.
  • Your headache occurs with a head injury.
  • Your headache is severe and localized to one eye with redness in that eye.
  • You are over age 50 and your headaches just began, especially with impaired vision and pain while chewing.

See your provider soon if:

  • Your headaches wake you up from sleep.
  • A headache lasts more than a few days.
  • Headaches are worse in the morning.
  • You have a history of headaches but they have changed in pattern or intensity.
  • You have headaches frequently, and there is no known cause.

What to expect at your health care provider's office   

Your health care provider will obtain your medical history and will perform an examination of your head, eyes, ears, nose, throat, neck, and nervous system.

The diagnosis is usually based on your history of symptoms. A "headache diary" may be helpful for recording information about headaches over a period of time. Your doctor may ask questions such as the following:

  • Is the headache located in the forehead, around the eyes, in the back of the head, near the temples, behind the eyeball, or all over?
  • Is the headache on one side only?
  • Is this a new type of headache for you?
  • Would you describe the headache as throbbing?
  • Is there a pressure or band-like sensation?
  • When does the headache occur? How long have you had headaches? How long does each headache last?
  • Does the headache awaken you from sleep? Are the headaches worse during the day and better at night?
  • Did other symptoms begin shortly after the headaches began? Do headaches occur repeatedly?
  • Does the headache reach maximum intensity over 1 to 2 hours?
  • Are the headaches worse when you are lying down? Standing up?
  • Are the headaches worse when you cough or strain?
  • Do they occur at a specific time related to your menstrual period?
  • What home treatment have you tried? How effective was it?

Diagnostic tests that may be performed include the following:

  • Head CT scan
  • Head MRI
  • Sinuses x-rays
  • Temporal artery biopsy
  • Lumbar puncture
If a migraine is diagnosed, medications that contain ergot may be prescribed. Temporal arteritis must be treated with steroids to help prevent blindness. Other disorders are treated as is appropriate.

Prevention   

The following healthy habits can lessen stress and reduce your chance of getting headaches:

  • Getting adequate sleep
  • Eating a healthy diet
  • Exercising regularly
  • Stretching your neck and upper body, especially if your work involves typing or using a computer
  • Learning proper posture
  • Quitting smoking
  • Learning to relax using meditation, deep breathing, yoga, or other techniques

References   

Lipton RB, Bigal ME, Steiner TJ, Silberstein SD, Olesen J. Classification of primary headaches. Neurology. August 10, 2004;63(3):427-35.

American Council for Headache Education. Headache Information page. Available at: http://www.achenet.org/understanding /. Accessed March 23, 2005.

Snow V. Pharmacologic management of acute attacks of migraine and prevention of migraine headache. Ann Intern Med. 2002; 137(10): 840-849.

Kaniecki RG. Migraine and tension-type headache: an assessment of challenges in diagnosis. Neurology. 2002; 58(9 Suppl 6): S15-20.

 

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