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Vioxx ( For Pain Relief )
May also be referred to as: Rofecoxib.
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Vioxx Can Provide 24-Hour Relief Of Osteoarthritis Pain To Help You Enjoy Everyday Things Again.
Managing pain isn’t about being able to climb Mount Everest or run a marathon. It’s about controlling the pain that keeps you from doing simple things, like taking a walk or bending down to build sandcastles with your child.
Vioxx can help you do the things you enjoy, with all-day, all-night relief. One little tablet, taken just once a day, can provide 24-hour relief from osteoarthritis pain. And Vioxx can be taken with or without food, so you don’t have to worry about scheduling it around meals.
In clinical studies lasting up to 21 months, osteoarthritis patients taking one small tablet of Vioxx reported a significant reduction in arthritis pain. Once-daily Vioxx continued to provide relief from pain for the length of the studies.
Possible uses of Vioxx
Vioxx is a nonsteroidal anti-inflammatory drug (NSAID) known as a COX-2
inhibitor used to relieve the symptoms of osteoarthritis and to treat pain and
menstrual discomfort.
How to take Vioxx
The usual dose of Vioxx for acute pain syndromes and menstrual cramps (primary
dysmenorrhea) is 50 mg once daily for no longer than 5 days. The usual dose of
Vioxx for treatment of osteoarthritis is 12.5 mg daily although some patients
may benefit from 25 mg daily. The maximum daily dose should not exceed 25 mg.
This medicine may be taken on an empty stomach or with food. STORE THIS MEDICINE
at room temperature at 77 degrees F (25 degrees C) in a tightly-closed
container, away from heat, moisture, and light. IF YOU MISS A DOSE OF THIS
MEDICINE and you are taking 1 dose daily, take the missed dose if you remember
the same day. Skip the missed dose if you do not remember until the next day. DO
NOT take 2 doses at once.
Side Effects
SIDE EFFECTS that may occur while taking Vioxx include weakness or nausea. If
they continue or are bothersome, check with your doctor. CHECK WITH YOUR DOCTOR
AS SOON AS POSSIBLE if you experience itching or skin rash, swelling of the feet
or ankles, unexpected weight gain, vomiting material that looks like coffee
grounds, or blood in stool or vomit. CONTACT YOUR DOCTOR IMMEDIATELY if you
experience swelling of hands, face, lips, eyes, throat, or tongue; difficulty
swallowing or breathing; hoarseness; flu-like symptoms; sluggishness; yellowing
of the skin or eyes; stomach pain; dark urine or pale stools; or unusual
fatigue. If you notice other effects not listed above, contact your doctor,
nurse, or pharmacist.
Precautions
DO NOT TAKE VIOXX IF YOU HAVE HAD A SEVERE ALLERGIC REACTION to aspirin or any
medicine containing aspirin or to a nonsteroidal anti-inflammatory drug (such as
Feldene, Motrin, Naprosyn, Clinoril). A severe reaction includes a severe rash,
hives, breathing difficulties, or dizziness. If you have a question about
whether you are allergic to this medicine or if a certain medicine is a
nonsteroidal anti-inflammatory drug, contact your doctor or pharmacist. IF YOU
EXPERIENCE difficulty breathing; tightness of chest; swelling of eyelids, face,
or lips; or if you develop a rash or hives, tell your doctor immediately. Do not
take any more doses of this medicine unless your doctor tells you to do so. DO
NOT EXCEED THE RECOMMENDED DOSE or take this medicine for longer than prescribed
without checking with your doctor. KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS
while you are using this medicine. ALCOHOL WARNING: If you consume 3 or more
alcoholic drinks every day, ask your doctor whether you should take this
medicine or other pain relievers/fever reducers. This medicine may cause stomach
bleeding. BEFORE YOU BEGIN TAKING ANY NEW MEDICINE, either prescription or
over-the-counter, check with your doctor or pharmacist. This includes any
medicines that contain ibuprofen, naproxen, or ketoprofen. FOR WOMEN: IF YOU
PLAN ON BECOMING PREGNANT, discuss with your doctor the benefits and risks of
using this medicine during pregnancy. IT IS UNKNOWN IF THIS MEDICINE IS EXCRETED
in breast milk. DO NOT BREAST-FEED while taking this medicine.
Drug Interactions
Inform your doctor about all the medicines you take with and without a
prescription.
Missed Dose
If you miss a dose, skip the missed dose and resume your usual dosing schedule.
Do not "double-up" the amount used to catch up.
Storage
Store at room temperature away from sunlight. Keep this and all medications out
of the reach of children.
Notes
DO NOT SHARE THIS MEDICINE with others for whom it was not prescribed. DO NOT
USE THIS MEDICINE for other health conditions. KEEP THIS PRODUCT out of the
reach of children. IF USING THIS MEDICINE FOR AN EXTENDED PERIOD OF TIME, obtain
refills before your supply runs out.
VIOXX (rofecoxib) is described chemically as
4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone. It has the following
chemical structure:

Rofecoxib is a white to off-white to light yellow powder. It is sparingly
soluble in acetone, slightly soluble in methanol and isopropyl acetate, very
slightly soluble in ethanol, practically insoluble in octanol, and insoluble in
water. The empirical formula for rofecoxib is C17H14O4S, and the molecular
weight is 314.36.
Each tablet of VIOXX for oral administration contains either 12.5 mg, 25 mg,
or 50 mg of rofecoxib and the following inactive ingredients: croscarmellose
sodium, hydroxypropyl cellulose, lactose, magnesium stearate, microcrystalline
cellulose, and yellow ferric oxide. The 50 mg tablets also contain red ferric
oxide.
Each 5 mL of the oral suspension contains either 12.5 or 25 mg of rofecoxib
and the following inactive ingredients: citric acid (monohydrate), sodium
citrate (dihydrate), sorbitol solution, strawberry flavor, xanthan gum, and
purified water. Added as preservatives are sodium methylparaben 0.13% and sodium
propylparaben 0.02%.
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