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Wellbutrin ( Bupropion HCL )
Wellbutrin is an antidepressant that works by affecting two chemicals in the brain that are believed to help regulate your mood (dopamine and norepinephrine).
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Directions
This wellbutrin may be taken with food if stomach upset occurs. Take doses at regularly scheduled times each day. Do not take more or less wellbutrin than prescribed and follow your doctor's instructions carefully. Do not stop taking this wellbutrin without notifying your doctor. Since this drug may cause sleeplessness at first, it is best not to take this near bedtime. It may take 4 weeks or more before the full effects of this wellbutrin are noticed.
Patient information
This wellbutrin may cause dry mouth, headache, increased sweating, nausea/vomiting, constipation, anxiety, fatigue and blurred vision.. If these effects persist or worsen, notify your doctor. Report promptly: unusual weight loss or gain, palpitations, agitation, trouble sleeping. Unlikely but report promptly: tremor, dizziness, fainting, mood changes, slowed movements, difficulty urinating, decreased sex drive, and drowsiness. Very unlikely but report promptly: seizures, mental problems, fever, muscle aches, yellowing of the eyes or skin. In the unlikely event you have an allergic reaction to this drug, seek medical attention immediately. Symptoms may include trouble breathing, rash, itching, swelling, or severe dizziness. If you notice other effects not listed above, contact your doctor or pharmacist.
Precautions
Before taking Wellbutrin SR, tell your doctor if you have: history of seizures or head injury or brain tumor, heart disease, liver or kidney disease, eating disorder, diabetes, alcohol dependence, any allergies, the intent to quit smoking. Because of the possibility this drug will make you dizzy and affect coordination, do not drive or operate machinery until you get used to the drug's effects. Limit or avoid consumption of alcoholic beverages; alcohol can increase your risk of seizures. Chronic alcohol users who suddenly stop the intake of alcohol while taking Wellbutrin SR may increase the risk of having seizures. Suddenly stopping certain tranquilizers (e.g., diazepam, chlordiazepoxide) is not recommended because doing so may increase the risk of having seizures. Elderly patients may be more sensitive to the effects of this drug. Tell your doctor if you are pregnant or plan to become pregnant before taking this drug. This drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.
Drug interactions
Before taking Wellbutirn SR tell your doctor of all nonprescription and prescription wellbutrins you may use especially: MAO inhibitors (e.g., isocarboxazid, phenelzine, tranylcypromine, pargyline, selegiline, linezolid, furazolidone), levodopa, ritonavir, corticosteroids (e.g. prednisone), sedatives, adrenaline-like stimulants (e.g., ephedrine), products containing nicotine (e.g., patches or gum). Also report use of drugs which might increase seizure risk (decrease seizure threshold) such as: phenothiazines (e.g., chlorpromazine), tricyclic antidepressants (e.g., amitriptyline), isoniazid (INH), theophylline. Excess caffeine intake can increase the chance of seizures with this drug. Check all nonprescription/prescription drug labels for caffeine. Consult your doctor or pharmacist. Certain products used to help quit smoking contains Wellbutrin SR. Do not take that product while using this one. Do not start or stop any medicine without doctor or pharmacist approval.
WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone
class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin
re-uptake inhibitor, or other known antidepressant agents. Its structure closely
resembles that of diethylpropion; it is related to phenylethylamines. It is
designated as (±)-1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone
hydrochloride. The molecular weight is 276.2. The empirical formula is C13H18ClNO·HCl.
Bupropion hydrochloride powder is white, crystalline, and highly soluble in
water. It has a bitter taste and produces the sensation of local anesthesia on
the oral mucosa. The structural formula is:
WELLBUTRIN is supplied for oral administration as 75-mg (yellow-gold) and
100-mg (red) film-coated tablets. Each tablet contains the labeled amount of
bupropion hydrochloride and the inactive ingredients: 75-mg tablet –
D&C Yellow No. 10 Lake, FD&C Yellow No. 6 Lake, hydroxypropyl cellulose,
hypromellose, microcrystalline cellulose, polyethylene glycol, talc, and
titanium dioxide; 100-mg tablet – FD&C Red No. 40 Lake, FD&C Yellow
No. 6 Lake, hydroxypropyl cellulose, hypromellose, microcrystalline cellulose,
polyethylene glycol, talc, and titanium dioxide.
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